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Lupus Podcast July 2022
Professors Ed Vital and Eric Morand review the lupus literature from June and July. Join them as they discuss when to discontinue maintenance IST in lupus nephritis; biomarkers and key immune pathways, emerging therapies, and a comparison of anifrolumab and belimumab in SLE; as well as explaining what can be learnt from studies that don’t meet their endpoints.
Lupus Podcast May 2022
Join Professors Ed Vital and Maria Dall'Era as they review the literature from April to May 2022, including disparities in the risk of end-organ manifestations in SLE in relation to race and ethnicity, the association between high Type I interferon activity and class III/IV LN, as well as anifrolumab efficacy and safety by Type I interferon gene signature, determinants of prolonged remission in SLE, impact of belimumb on organ damage, and the latest data for iberdomide and obinutuzumab.
Joan Merrill Author Interview, May 2022
Professor Joan Merrill discusses the results from the Phase 2 trial of iberdomide in SLE. Iberdomide is a cereblon modulator that promotes degradation of the transcription factors Ikaros and Aiolos, which affect leukocyte development and autoimmunity. In this Phase 2 trial, Iberdomide was evaluated for the treatment of SLE. Patients were randomly assigned in a 2:2:1:2 ratio to receive oral iberdomide at a dose of 0.45, 0.30, or 0.15 mg, or placebo once daily for 24 weeks. A higher percentage of patients receiving iberdomide 0.45 mg achieved SRI-4 response than those receiving placebo.
Lupus Podcast March 2022
Join Professors Ed Vital and Laurent Arnaud as they review the literature from January to March 2022, including recent anifrolumab and iberdomide data, as well scoring systems, EULAR recommendations for cardiovascular risk management and the impact of belimumab on flare risk in lupus nephritis.